不同时期分离的淋病奈瑟菌对5种抗生素的敏感性研究

目的：研究杭州市不同时期分离的林病奈瑟菌对5种抗生素的敏感性。方法：用琼脂烯释法对门诊1998年7月～2001年10月分离的285株淋病奈瑟菌进行青霉素、四环素、壮观霉素、氧氟沙星及头孢曲松的最小抑菌浓度（MIC）测定，并就PPNG株和non-PPNG株菌的MIC值进行了比较。结果：青霉素、四环毒等5种抗生素MIC值2001年～1998年两者之间比较，青霉素、四环素等5种抗生素MIC值2001年与1998年两者之间比较，除壮观霉素没有变化外，其余都有显著变化，而氧氟沙星变化最大，PP-NG菌株与非PPNG株菌MIC值除氧氟沙星外均存在差异。结论：表明了杭州市淋病奈瑟菌5种抗生素耐药性变迁，以便为临床选择用药提供依据。

STUDY ON SUSCEPTIBILITY OF FIVE KINDS OF ANTIBIOTICS AGAINST NEISSE RIA GONORRHOEAE ISOLATED FROM HANG ZHOU IN DIFFERENT PERIODS

Objective:To study the susceptibility of five kinds of antibiotics against Neisseria gonorrhoeae isolated from Hangzhou in different periods Methods:Minimum inhibitory concentration (MIC) of penicillin,tetracyline,ceftriaxone,ofloxacin and spectinomycin to 285 strains of N gonorrhoeae isolated from 1998 to 2001 were determined using the agar dilution method,and the MIC values to PPNG and non PPNG strains were compared Results:The MIC values of 5 antibiotics(except spectinomycin) to the isolates in 2001 have changed significantly than that in 1998,and the changes of MIC values of ofloxacin was the biggest among them There was a difference in MIC values between PPNG and non PPNG (except ofloxacin) Conclusion:The study showed the changes of susceptibility of five kinds of antibiotics against N gonorrhoeae isolated from Hangzhou in different periods so that these findings provide laboratory evidence for the treatment of gonorrhea