Receptor for activated C kinase 1 stimulates nascent polypeptide-dependent translation arrest |
| |
Authors: | Kuroha Kazushige Akamatsu Mayuko Dimitrova Lyudmila Ito Takehiko Kato Yuki Shirahige Katsuhiko Inada Toshifumi |
| |
Institution: | Nagoya University, Chikusa-ku, Japan. |
| |
Abstract: | Nascent peptide-dependent translation arrest is crucial for the quality control of eukaryotic gene expression. Here we show that the receptor for activated C kinase 1 (RACK1) participates in nascent peptide-dependent translation arrest, and that its binding to the 40S subunit is crucial for this. Translation arrest by a nascent peptide results in Dom34/Hbs1-independent endonucleolytic cleavage of mRNA, and this is stimulated by RACK1. We propose that RACK1 stimulates the translation arrest that is induced by basic amino-acid sequences that leads to endonucleolytic cleavage of the mRNA, as well as to co-translational protein degradation. |
| |
Keywords: | translation arrest nascent peptide RACK1 mRNA quality control endonucleolytic cleavage |
本文献已被 PubMed 等数据库收录! |