Qualitative alterations in plasma esterases in BALB/c mice following the administration of diethylnitrosamine. |
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Authors: | K A Davidson R L Tyndall N K Clapp |
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Affiliation: | Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tenn. 37830 U.S.A. |
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Abstract: | Selected non-specific plasma esterases in female BALB/c mice, separated by polyacrylamide gel electrophoresis, were qualitatively altered following treatment of the mice with diethylnitrosamine (DEN). These alterations include a decreased preference for naphthyl butyrate as a substrate relative to naphthyl acetate; decreased sensitivity to enhancement by divalent cations such as Ca2+, Mg2+, and Mn2; and an increased sensitivity to inhibition by eserine. All esterase species affected were also quantitatively altered and some were testosterone-dependent. |
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Keywords: | DEN diethylnitrosamine PMSF phenylmethylsulfonyl fluoride |
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