Electrochemical study on behavior of EuMo2 complex and its interaction with DNA |
| |
Authors: | Li Zhifeng Kang Jingwan Lu Xiaoquan |
| |
Institution: | School of life Science and Chemistry, Tianshui Normal University, Tianshui, PR China. |
| |
Abstract: | The electrochemical behavior of complex EuMo2 (Mo = Morin, 2',3,4'5,7-pentahydroxyflavone) and its interactions with calf thymus DNA were studied using cyclic voltammetry (CV) and double potential step chronocoulometry (DPSCC) at glass carbon electrode (GCE) and DNA modified GCE, respectively. Information such as diffusion coefficient (D), rate constant (ks) of EuMo2 and intrinsic binding constant (K), binding numbers (n) of bound species per DNA (bp) were obtained. EuMo2 can bind to DNA, and the binding mode is intercalation. By nonlinear fitting with Langmuir equation, a K of 1.02 x 10(6) M-1 and an n of 1 were obtained. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|