| 肌肉生长抑制素基因在哺乳动物中的最新研究进展 |
| |
| 作者姓名： | 高丽 谌颜 扈廷茂 李光鹏 |
| |
| 作者单位： | 内蒙古大学生殖生物学与生物技术教育部重点实验室, 呼和浩特 010021 |
| |
| 基金项目： | 国家科技重大专项（2013ZX08007-002）资助。 |
| |
| 摘 要： | 肌肉生长抑制素（myostatin，MSTN），也称为生长分化因子8（GDF8），是转化生长因子β（TGF-β）超家族成员，主要在骨骼肌中表达，在负向调控肌细胞的生长发育中起关键作用。本文对MSTN研究的最新进展进行了综述，讨论了MSTN信号通路与其他通路之间的相互关系，重点阐述了试验条件下MSTN对肌肉发育相关基因的作用，介绍了通过基因操作或使用抗体的方法抑制MSTN的表达对于提高动物产肉量、治疗肌肉萎缩等疾病以及延缓衰老的重要意义。
|
| 关 键 词： | 肌细胞 MSTN信号通路 基因敲除/敲减 肌肉生长抑制素 哺乳动物 |
| 收稿时间： | 2014-07-08 |
The Latest Research Progress of Myostatin in Mammals |
| |
| Authors: | GAO Li CHEN Yan HU Ting-mao LI Guang-peng |
| |
| Institution: | Key Laboratory of National Education Ministry for Mammalian Reproductive Biology and Biotechnology, Inner Mongolia University, Hohhot 010021, China |
| |
| Abstract: | Myostatin, also known as growth/differentiation factor-8 (GDF-8), a member of transforming growth factor β (TGF-β) family, is mostly expressed in skeletal muscles and plays crucial roles in the negative regulation of muscle development. In this paper, we reviewed the latest research progress of MSTN in mammals, mainly discussed the relationship between MSTN signal pathway and other related signal pathways， and especially summarized the effect of myostatin on gene expression associated with muscle development under experimental conditions. This review also introduced the significance for knockout or knockdown of MSTN by genetic manipulation or using antibodies in increasing muscle growth in transgenic animals, clinic treatment of diseases such as muscular dystrophy, and delaying of aging. |
| |
| Keywords: | muscle cells MSTN signal pathway gene knockout/knockdown myostatin mammal |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《》浏览原始摘要信息 |
| 点击此处可从《》下载免费的PDF全文 |
