| Survivin在细胞分裂中的作用 |
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| 引用本文： | 王建英,兰邹然,于兴华,李云龙. Survivin在细胞分裂中的作用[J]. 细胞生物学杂志, 2006, 28(4): 566-570 |
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| 作者姓名： | 王建英 兰邹然 于兴华 李云龙 |
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| 作者单位： | 山东师范大学生命科学学院动物抗性重点实验室 济南250014(王建英，李云龙)，中国海洋大学生命科学与技术学部 青岛266003(兰邹然)，莱阳农学院生命科学学院 青岛266109(于兴华) |
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| 摘 要： | Survivin是凋亡蛋白抑制因子家族的一个新成员,它主要在细胞周期G2/M期表达,并有两种不同的亚细胞定位。Survivin与有丝分裂细胞周期的启动有关,并在有丝分裂中的中心体装配、纺锤体检验点的监控、胞质分裂等过程中发挥作用。Survivin在减数分裂中也有一定的作用,目前研究甚少。Survivin发挥功能的首要前提是通过主要的有丝分裂激酶p34cdc2-cyclinB1使Thr34磷酸化,其表达水平受很多因素的调节。
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| 关 键 词： | Survivin 有丝分裂 减数分裂 |
| 收稿时间： | 2005-10-08 |
| 修稿时间： | 2006-04-14 |
The Fuction of Survivin in Cell Division |
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| Jian-Ying Wang,Zou-Ran Lan,Xing-Hua Yu,Yun-Long Li. The Fuction of Survivin in Cell Division[J]. Chinese Journal of Cell Biology, 2006, 28(4): 566-570 |
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| Authors: | Jian-Ying Wang Zou-Ran Lan Xing-Hua Yu Yun-Long Li |
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| Affiliation: | 1Key Laboratory of Animal Resistance Research, College of Life Science, Shandong Normal University, Jinan 250014, China; 2Life Sciences and Technology College, Ocean University of China, Qingdao 266003, China; 3College of Life Science, Laiyang Agriculture Academy, Qingdao 266109, China |
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| Abstract: | Survivin is a new inhibitor of apoptosis (IAP) protein. Survivin, is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner and it has two different subcellular localization. Survivin initiates cell cycle entry and is required for centrosome assembly, spindle assembly checkpoint surveillance and cytokinesis. Survivin also plays a role in meiosis, but there are only a few reports to date. The survivin activity resulted from the phosphorylation of Thr34 by the mitotic kinase complex p34cdc2-cyclin B1, many factors regulate its expression level. |
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| Keywords: | survivin mitosis meiosis |
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