A multifunctional cyclic nucleotide- and Ca2+-independent protein kinase from rabbit skeletal muscle |
| |
Authors: | T J Singh A Akatsuka K P Huang R K Sharma S W Tam J H Wang |
| |
Affiliation: | 2. National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20205 USA |
| |
Abstract: | A cyclic nucleotide- and Ca2+-independent protein kinase, initially identified as a glycogen synthase kinase (Itarte, E. and Huang, K.-P. (1979) J. Biol. Chem. , 4052–4057), was also found to phosphorylate phosphorylase kinase and troponin from skeletal muscle as well as myosin light chain and myosin light chain kinase from both smooth and skeletal muscles. With the exception of myosin light chain from skeletal muscle, all the above-mentioned proteins are also substrates for the multifunctional cAMP-dependent protein kinase. The results suggest that this cyclic nucleotide- and Ca2+-independent protein kinase, like cAMP-dependent protein kinase, may have multiple cellular functions. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|