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Global nucleosome occupancy in yeast |
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| Authors: | Bradley?E?Bernstein mailto:bbernstein@partners.org" title=" bbernstein@partners.org" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Chih?Long?Liu,Emily?L?Humphrey,Ethan?O?Perlstein,Stuart?L?Schreiber mailto:stuart_schreiber@harvard.edu" title=" stuart_schreiber@harvard.edu" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author |
| Affiliation: | (1) Department of Chemistry and Chemical Biology, Bauer Center for Genomics Research, and Howard Hughes Medical Institute, Harvard University, 12 Oxford Street, 02138 Cambridge, MA, USA;(2) Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 02115 Boston, MA, USA;(3) Biological and Biomedical Sciences, Division of Medical Sciences, Harvard Medical School, 02115 Boston, MA, USA;(4) Department of Molecular and Cellular Biology, Harvard University, 02138 Cambridge, MA, USA |
| Abstract: | BackgroundAlthough eukaryotic genomes are generally thought to be entirely chromatin-associated, the activated PHO5 promoter in yeast is largely devoid of nucleosomes. We systematically evaluated nucleosome occupancy in yeast promoters by immunoprecipitating nucleosomal DNA and quantifying enrichment by microarrays. |
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