Biotransformation of glycyrrhizin by Aspergillus niger |
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| Authors: | Hongzhi Huang Heshui Yu Jie Zhang Liping Kang Bing Feng Xinbo Song |
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| Institution: | 1. Beijing Institute of Radiation Medicine, Beijing, People's Republic of China;2. Department of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China;3. Department of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China |
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| Abstract: | Biotransformation of glycyrrhizin by Aspergillus niger was investigated and one new compound (1) and one known compound (2) were isolated and identified from the biotransformation products. These were 7β,15α-dihydroxy-3,11-dioxo-oleana-12-en-30-oic acid (1) and 15α-hydroxy-3,11-dione-oleana-12-en-30-oic acid (2). A biotransformation pathway was proposed from HPLC analyses at different reaction times. The biotransformation by A. niger included two stages: first, the two glucuronic acid residues at the C-3 position of glycyrrhizin were hydrolyzed to produce glycyrrhetic acid; and second, glycyrrhetic acid was oxidized and hydroxylated to compounds 1 and 2. |
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| Keywords: | Glycyrrhizin biotransformation Aspergillus niger |
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