Directional Modifications of Resibufogenin by Mucor subtilissimus and Pseudomonas aeruginosa |
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| Authors: | Jixun Zhan Yuanxing Zhang Wenhui Liu Hongzhu Guo Dean Guo |
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| Institution: | 1. State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences, Peking University 100083 Beijing;2. State Key Laboratory of Bioreactor Engineering East China University of Science and Technology 200237 Shanghai |
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| Abstract: | Directional modifications of resibufogenin 1 by Mucor subtilissimus and Pseudomonas aeruginosa were carried out. The substrate was hydroxylated at C-12 by M. subtilissimus AS 3.2454, from which a major product 12-hydroxyresibufogenin 2 was obtained. Then product 2 was dehydrogenated by P. aeruginosa AS 1.860, which resulted in a new compound 12β-hydroxy-3-keto-resibufogenin 3. |
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| Keywords: | Directional Modifications Resibufogenin Hydroxylation Mucor Subtilissimus Dehydrogenation Pseudomonas Aeruginosa |
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