2-Bromoacetamidopyridine: a new chemical probe of the active site of histidine decarboxylase from Lactobacillus 30a |
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| Authors: | R S Lane G Thill |
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| Institution: | 1. Department of Medicine Albert Einstein College of Medicine 1300 Morris Park Avenue Bronx, New York 10461 USA;2. Department of Cell Biology Albert Einstein College of Medicine 1300 Morris Park Avenue Bronx, New York 10461 USA;3. The Liver Research Center Albert Einstein College of Medicine 1300 Morris Park Avenue Bronx, New York 10461 USA |
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| Abstract: | In rats fasted for 24–30 hours, albumin mRNA sequences are released from membrane-bound polysomes to enter the free cytosol fraction. A significant portion of these sequences are present in albumin mRNPs, distinguished from free albumin mRNA and 40S subunit complexes by Cs2SO4 equilibrium density centrifugation. Refeeding a mixture of 20 amino acids restores albumin mRNA to membrane-bound polysomes, demonstrating the importance of amino acid supply in the mRNP-polysome equilibrium and in regulation of albumin synthesis. |
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| Keywords: | To whom correspondence should be addressed: Department of Biochemistry University of South Alabama College of Medicine Mobile Alabama 36688 |
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