Asymmetric competitive suppression between strains of dengue virus |
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Authors: | Kim M Pepin Kalli Lambeth Kathryn A Hanley |
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Institution: | (1) Department of Biology, New Mexico State University, Las Cruces, NM 88003, USA |
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Abstract: | Background Within-host competition between strains of a vector-borne pathogen can affect strain frequencies in both the host and vector,
thereby affecting viral population dynamics. However little is known about inter-strain competition in one of the most genetically
diverse and epidemiologically important mosquito-borne RNA virus: dengue virus (DENV). To assess the strength and symmetry
of intra-host competition among different strains of DENV, the effect of mixed infection of two DENV serotypes, DENV2 and
DENV4, on the replication of each in cultured mosquito cells was tested. The number of infectious particles produced by each
DENV strain in mixed infections was compared to that in single infections to determine whether replication of each strain
was decreased in the presence of the other strain (i.e., competition). The two DENV strains were added to cells either simultaneously
(coinfection) or with a 1 or 6-hour time lag between first and second serotype (superinfection). |
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Keywords: | |
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