Biochemical and electropharmaceutical studies with tricyclic antidepressants in rat and guinea-pig cerebral cortex. |
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| Authors: | A Sattin T W Stone D A Taylor |
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| Affiliation: | 1. Department of Psychiatry, Indiana University School of Medicine, 1100 W. Michigan Street, Indianapolis, Indiana 46202, U.S.A.;7. Department of Physiology, St. George''s Hospital Medical School, University of London, London, U.K.;71. Department of Pharmacology, University of Colorado Medical Center, Denver, Colorado, U.S.A. |
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| Abstract: | Chopped guinea pig cerebral cortex was incubated with a series of antidepressant drugs which produced increases in the cyclic AMP content of the tissue. These effects were partially or wholly blocked by theophylline, suggesting that they were mediated by endogenous production, release and action of adenosine. A similar series of drugs was iontophoretically ejected on rat cerebral cortical neurons where augmentation of concurrently ejected adenosine was observed as slowing of the rate of cell firing. Pharmacological correlations between the two sets of data suggest a common mechanism of action. |
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| Keywords: | To whom reprint requests should be sent |
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