A Novel Campylobacter jejuni Two-Component Regulatory System Important for Temperature-Dependent Growth and Colonization |
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| Authors: | Ana M. Br s, Shimonti Chatterjee, Brendan W. Wren, Diane G. Newell, Julian M. Ketley |
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| Affiliation: | Department of Genetics, University of Leicester, Leicester, United Kingdom. |
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| Abstract: | Campylobacter jejuni colonizes the intestines of domestic and wild animals and is a common cause of human diarrheal disease. We identified a two-component regulatory system, designated the RacR-RacS (reduced ability to colonize) system, that is involved in a temperature-dependent signalling pathway. A mutation of the response regulator gene racR reduced the organism's ability to colonize the chicken intestinal tract and resulted in temperature-dependent changes in its protein profile and growth characteristics. |
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