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Preparation and Investigation of Bioactive Transferrin-Iron Complexes Formed with Different Synergistic Anions |
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| Authors: | Judit Gálicza Andrea Vargová Viktor Sándor Csongor Kálmán Orbán Csaba Dezs? András Beáta ábrahám Szabolcs Lányi Ferenc Kilár |
| Affiliation: | (1) Applied Chemistry and Material Science, Politehnica University of Bucharest, 010737 Bucharest, Romania;(2) Department of Analytical and Environmental Chemistry, University of P?cs, 7624 P?cs, Hungary;(3) Faculty of Technological and Social Sciences, Technical Science Department, Sapientia Hungarian University of Transylvania, 530104 Miercurea Ciuc, Romania;(4) Institute of Bioanalysis, University of P?cs, Medical School, 7624 P?cs, Hungary;(5) Department of Food Science, Sapientia Hungarian University of Transylvania, 530104 Miercurea Ciuc, Romania;(6) Department of Chemical and Environmental Process Engineering, Budapest University of Technology and Economics, Műegyetem Whf., nr. 3, 1514 Budapest, Hungary |
| Abstract: | Human serum transferrin has a potential for drug-delivery systems. Oxalate and aziridine-carboxylate was conjugated to serum transferrin in order to transport into the targeted cancer cells via transferrin-receptor mediated endocytosis. Capillary zone electrophoresis and capillary isoelectric focusing were used to analyze the effectiveness of complexation reactions. The electropherograms show the differences between iron-free- and iron-complexed molecular forms of human serum transferrin. The iron-complexed transferrin sample containing the different anions as synergistic complexing agents were characterized by different electrophoretic parameters. |
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