Validation of an LC-MS/MS method to determine five immunosuppressants with deuterated internal standards including MPA |
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Authors: | Armin Buchwald Karl Winkler Thomas Epting |
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Institution: | (1) Division of Clinical Chemistry, Department of Medicine, University Medical Center Freiburg, Hugstetterstrasse 55, 79106 Freiburg, Germany |
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Abstract: | Background Therapeutic drug monitoring of immunosuppressive drugs in organ-transplanted patients is crucial to prevent intoxication or
transplant rejection due to inadequate dosage. The commonly used immunoassays have been gradually undergoing replacement by
mass spectrometry, since this physical method offers both a higher sensitivity and specificity. However, a switch should be
carefully considered because it is a challenging procedure and needs to be thoroughly validated. |
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