MDM2 SNP309 polymorphism and breast cancer risk: a meta-analysis |
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Authors: | Erjiang Zhao Dan Cui Ling Yuan Weiquan Lu |
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Institution: | (1) Department of Epidemiology and Biostatistics, Public Health School of Zhengzhou University, Zhengzhou, 450001, China;(2) Department of Radiotherapy, Henan Tumor Hospital, Zhengzhou, 450003, China;(3) Department of Epidemiology, Henan Tumor Institute, Zhengzhou, 450003, China; |
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Abstract: | The mouse double minute 2 (MDM2) gene encodes a phosphoprotein that interacts with P53 and negatively regulates its activity.
SNP309 polymorphism (T-G) in the promoter of MDM2 gene has been reported to be associated with enhanced MDM2 expression and
tumor development. Many published studies have evaluated the association between MDM2 SNP309 polymorphism and breast cancer
risk. However, the results were inconsistent. We combined and analyzed the data from 19 case–control studies including 14,450
cases and 13,382 controls. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of
the association between MDM2 SNP309 polymorphism and breast cancer risk. No significant association was found in all genetic
models in overall population. However, in subgroup analysis by ethnicity (4 studies in Asian group, 13 studies in European
group, 2 studies of mixed population which were separated into 2 European population group and 2 African population group),
we found an increased breast cancer susceptibility for GT versus TT (OR = 1.31, 95% CI = 1.03–1.67) in Asian population and
for GT versus TT (OR = 1.31, 95% CI = 1.03–1.66) in African population. When stratified by family history status (5 studies
in familial breast cancer group, 5 studies in sporadic breast cancer group), homozygous subjects of sporadic breast cases
carrying the T309G G allele exhibited elevated breast cancer risk (OR = 1.35, 95% CI = 1.00–1.82), whereas heterozygous carriers
did not show significant association with breast cancer risk for GT vs. TT (OR = 1.26, 95% CI = 0.84–1.87). Our meta–analysis
suggests that MDM2 SNP309 polymorphism may increase the risk to breast cancer in Asian and African population. |
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