Recognition of the neural chemoattractant Netrin-1 by integrins alpha6beta4 and alpha3beta1 regulates epithelial cell adhesion and migration |
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Authors: | Yebra Mayra Montgomery Anthony M P Diaferia Giuseppe R Kaido Thomas Silletti Steve Perez Brandon Just Margaret L Hildbrand Simone Hurford Rosemary Florkiewicz Elin Tessier-Lavigne Marc Cirulli Vincenzo |
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Institution: | Department of Pediatrics, The Whittier Institute for Diabetes, University of California, San Diego, La Jolla, CA 92037, USA. |
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Abstract: | Netrins, axon guidance cues in the CNS, have also been detected in epithelial tissues. In this study, using the embryonic pancreas as a model system, we show that Netrin-1 is expressed in a discrete population of epithelial cells, localizes to basal membranes, and specifically associates with elements of the extracellular matrix. We demonstrate that alpha6beta4 integrin mediates pancreatic epithelial cell adhesion to Netrin-1, whereas recruitment of alpha6beta4 and alpha3beta1 regulate the migration of CK19+/PDX1+ putative pancreatic progenitors on Netrin-1. These results provide evidence for the activation of epithelial cell adhesion and migration by a neural chemoattractant, and identify Netrin-1/integrin interactions as adhesive/guidance cues for epithelial cells. |
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