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Inward Rotating Spiral Waves in Glycolysis |
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| Authors: | Ronny Straube Satenik Vermeer Thomas Mair |
| Institution: | † Max-Planck-Institute for Dynamics of Complex Technical Systems, Systems Biology Group, Sandtorstr. 1, Magdeburg, Germany ‡ Biophysics Group, Institute of Experimental Physics, Otto-von-Guericke University, Universitätsplatz 2, Magdeburg, Germany § IFISC, Institute for Cross-Disciplinary Physics and Complex Systems (CSIC-UIB), Palma de Mallorca, Spain |
| Abstract: | We report on the first observation of inward rotating spiral waves (antispirals) in a biochemical reaction-diffusion system. Experiments are performed with extracts from yeast cells in an open spatial reactor. By increasing the protein concentration of the extract we observe a transition from outward to inward propagating waves of glycolytic activity. Numerical simulations with an allosteric model for the phosphofructokinase can reproduce these inward propagating waves over a wide range of parameters if the octameric structure of yeast phosphofructokinase is taken into account. |
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