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Glycosylation of human trophoblast integrins is stage and cell-type specific |
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| Authors: | Moss, Lenny Proakobphol, Akraporn Wiedmann, Tien-Wen Fisher, Susan J. Damsky, Caroline H. |
| Affiliation: | 1Department of Stomatology, Reproductive Sciences, University of California SanFrancisco,CA 94143 2Department of Anatomy, Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143 3Obstetrics Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143 4Department of Pharmaceutical Chemistry, University of California San Francisco San Francisco, CA 94143 5Department of Nuclear Medicine, Stanford University Stanford, CA, USA. |
| Abstract: | Cytotrophoblasts are the specialized epithelial cells of theplacenta. During the first trimester, a subpopulation of chorionicvillas cytotrophoblasts differentiates along an invasive pathwayand penetrates the maternal endo-metrium, decidua and spiralarterioles. Cytotrophoblast invasiveness declines rapidly duringthe second half of gestation. Isolated cytotrophoblasts of differentgestational ages retain this differential invasiveness in culture.To determine whether the properties of integrin receptors forextracellular matrix molecules differ between invasive and non-invasivecytotrophoblasts, detergent extracts of isolated cytotrophoblastsof different gestational ages, and of first-trimester villousfibroblasts, were immunoprecipitated with subunit-specific anti- |
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