CEACAMs: their role in physiology and pathophysiology |
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Authors: | Kuespert Katharina Pils Stefan Hauck Christof R |
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Institution: | Lehrstuhl Zellbiologie, Fachbereich Biologie X908, Universität Konstanz, Universitätsstrasse 10, 78457 Konstanz, Germany |
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Abstract: | Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to a group of mammalian immunoglobulin-related glycoproteins. They are involved in cell-cell recognition and modulate cellular processes that range from the shaping of tissue architecture and neovascularization to the regulation of insulin homeostasis and T-cell proliferation. CEACAMs have also been identified as receptors for host-specific viruses and bacteria in mice and humans, respectively, making these proteins an interesting example of pathogen-host co-evolution. Forward and reverse genetics in the mouse now provide powerful novel models to elucidate the action of CEACAM family members in vivo. |
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