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Expression of {beta}-galactoside {alpha}2,6-sialyltransferase does not alter the susceptibility of human colon cancer cells to NK-mediated cell lysis |
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| Authors: | Dall'Olio Fabio; Mariani Erminia; Tarozzi Andrea; Meneghetti Alessandra; Chiricolo Mariella; Lau Joseph T Y; Facchini Andrea |
| Affiliation: | Dipartimento di Patologia Sperimentale, Università di Bologna 40126 Bologna 1Dipartimento di Medicina Interna e Gastroenterologia, Università di Bologna 40126 Bologna 2Laboratorio di Immunologia e Genetica, Istituto di Ricerca Codivilla-Putti I.O.R., 40136 Bologna, Italy 3Department of Molecular and Cellular Biology, Roswell Park Cancer Institute Buffalo, NY 14263, USA |
| Abstract: | The extent of processing of N-linked oligosaccharides and thesialylation of the target cell membranes has been positivelycorrelated with resistance to lysis mediated by NK cells, buta conclusive evidence has never been reached. Colon cancer tissuesexpress an increased activity of ß-ga-lactoside |
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