Rho-associated protein kinase is involved in establishing the cardiomyocyte contractile phenotype |
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Authors: | O V Stepanova A V Chadin A G Masyutin T G Kulikova Ya V Gurin I A Sergeeva V P Shirinsky |
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Institution: | 1.Institute of Experimental Cardiology,Russian Cardiology Research and Production Center,Moscow,Russia;2.Russian State Medical University,Moscow,Russia |
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Abstract: | We have shown that Y-27632, an inhibitor of Rho-associated kinase (ROCK), delays sarcomere assembly in cultured rat neonatal
cardiomyocytes pretreated with angiotensin II. Y-27632 affects the beat rate of cardiomyocytes, but this effect is only observed
at high cell density and, therefore, seems to be related to impairment of cell-cell interactions. Consistent with this suggestion,
ROCK2 is localized in myofibrillar Z-disks of human myocardium as well as in intercalated disks. We propose that ROCK participates
in maturation of the myocardial contractile system through phosphorylation of its molecular targets in Z-disks and in intercalated
disks. |
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