Phospholipase D in brain function and Alzheimer's disease |
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Authors: | Tiago Gil Oliveira Gilbert Di Paolo |
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Affiliation: | 1. Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer''s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA;2. Life and Health Science Research Institute, School of Health Sciences, University of Minho, 4710-057 Braga, Portugal |
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Abstract: | Alzheimer's disease is the most common neurodegenerative disorder. Although lipids are major constituents of brain, their role in Alzheimer's disease pathogenesis is poorly understood. Much attention has been given to cholesterol, but growing evidence suggests that other lipids, such as phospholipids, might play an important role in this disorder. In this review, we will summarize the evidence linking phospholipase D, a phosphatidic acid-synthesizing enzyme, to multiple aspects of normal brain function and to Alzheimer's disease. The role of phospholipase D in signaling mechanisms downstream of beta-amyloid as well as in the trafficking and processing of amyloid precursor protein will be emphasized. |
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Keywords: | Lipid enzyme Lipid metabolism Phospholipid Neurodegeneration Neurodegenerative disorder Neuronal function |
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