Proposed mechanism for lipoprotein remodelling in the brain |
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Authors: | Chunjiang Yu Katherine L. YoumansMary J. LaDu |
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Affiliation: | Department of Anatomy and Cell Biology, University of Illinois at Chicago, 808 S. Wood St, CME Room 578, MC 512, Chicago, IL 60612, USA |
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Abstract: | Lipoprotein remodelling in the periphery has been extensively studied. For example, the processing of nascent apoAI particles to cholesterol-loaded HDL lipoproteins during reverse cholesterol transport involves a series of enzymes, transporters in peripheral tissue, as well as other apolipoproteins and lipoproteins. These extensive modifications and interconversions are well defined. Here, we present the hypothesis that a similar process occurs within the blood brain barrier (BBB) via glia-secreted lipid-poor apoE particles undergoing remodelling to become mature central nervous system (CNS) lipoproteins. We further pose several pressing issues and future directions for the study of lipoproteins in the brain. |
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Keywords: | Lipid transport ApoE Lipoprotein Brain |
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