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Bay K 8644 induce enhancement of K+ current in both single heart cell and smooth muscle cell |
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| Authors: | J -F Renaud G Bkaily M Benabderrazik D Jacques N Sperelakis |
| Institution: | (1) Groupe de Recherches Servier, Fondax, 7 rue Ampère, 92800 Puteaux, France;(2) Department of Biophysics, Faculty of Medicine, University of Sherbrooke, J1H SN4 Sherbrooke, Québec, Canada;(3) Department of Physiology and Biophysics, School of Medicine, University of Cincinnati, Cincinnati, Ohio, USA |
| Abstract: | Summary The effects of the Ca2+ agonist Bay K 8644 on outward potassium currents have been studied in single ventricular cells of chick embryo and aortic single cells of rabbit using the whole-cell patch clamp technique. Bay K 8644 was found to increase lK in both heart and aortic single cells. This effect of Bay K 8644 on both muscle was reversed by Mn2+ and blocked by 20 mM TEA. The Bay K 8644 potassium I/V curve of single heart cell had a N shape, which is Ca2+ dependent. These data strongly suggest that Bay K 8644 increases a gK(ca) in both aortic and heart muscle. |
| Keywords: | heart cells smooth muscle Bay K 8644 K+ current patch clamp |
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