Synthesis of polyamine derivatives having non-hypotensive Ca2 +-permeable AMPA receptor antagonist activity |
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| Authors: | Yoneda Y Kawajiri S Hasegawa A Kito F Katano S Takano E Mimura T |
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| Affiliation: | Medicinal Chemistry Research Laboratory, Daiichi Pharmaceutical Co, Ltd, Tokyo, Japan. yonedL0z@daiichipharm.co.jp |
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| Abstract: | In order to obtain non-hypotensive and Ca2+-permeable AMPA receptor antagonists, we have synthesized a series of 1,4-bis(4-piperidinylmethyl)diaminobutanes. Compounds 13b, c, f had desirable properties. |
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