ON THE RESTING STAGES OF THE JB-1 ASCITES TUMOUR |
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Authors: | P Bichel P Dombernowsky |
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Institution: | Cancer Research Institute, Radiumstationen, Aarhus, Denmark, and Finsen Institute, Department of Internal Medicine, Copenhagen, Denmark |
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Abstract: | Cytophotometric determination of single-cell DNA after repeated 3H-thymidine labelling of the JB-1 ascites tumour in the plateau phase of growth showed a massive accumulation of unlabelled cells with both G1 and G2 content. Autoradiography combined with cytophotometry or colcemid block demonstrated that some of these unlabelled cells were rapidly triggered into the cell cycle when plateau tumours were transferred to new hosts. This indicated that tumour cells may be held up in non-cycling stages corresponding to both the G1 and the G2 phase of the cell cycle. |
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