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Quantitative evaluation of the effectiveness of exposure of the joints to 239Pu and tributyl phosphate by the degree of leukopenia in rats
Authors:Z I Kalmykova  V A Chudin  Z S Men'shikh
Abstract:The efficiency of the combined effect of 239Pu and tributyl phosphate was estimated by the severity of leucopenia in Wistar rats using the regression method and comparing the value of the actual change with the expected one. It was shown that the additive effect of the two agents delivered simultaneously was only exceeded when their doses were the largest that is, approximate the acute levels. With levels ranging from subacute effective to minimum effective ones the additivity diminished.
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