2-(Anilinomethyl)imidazolines as alpha(1)-adrenoceptor agonists: the identification of alpha(1A) subtype selective 2'-carboxylic acid esters and amides |
| |
| Authors: | Bishop M J Berman J Bigham E C Garrison D T Gobel M J Hodson S J Irving P E Liacos J A Minick D J Navas F Saussy D L Speake J D |
| |
| Institution: | GlaxoSmithKline, 5Moore Drive, Research Triangle Park, NC 27709, USA. mjb45288@glaxowellcome.com |
| |
| Abstract: | 2-(Anilinomethyl)imidazolines with 2'-esters or 2'-amides are potent agonists of the cloned human alpha(1)-adrenoceptors in vitro. The size and shape of the ortho substituent can have significant effects on the potency, efficacy, and subtype selectivity of these 2-(anilinomethyl)imidazolines. alpha(1A)-subtype selective agonists have been identified. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
