Regulation of the synthesis of adenylate cyclase in Escherichia coli by the cAMP -- cAMP receptor protein complex |
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| Authors: | Irene H. Majerfeld Diann Miller Eva Spitz H. V. Rickenberg |
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| Affiliation: | (1) Department of Molecular and Cellular Biology, National Jewish Hospital and Research Center, 3800 Fast Collax Avenue, 80206 Denver, Colorado, USA;(2) Department of Biochemistry, Biophysics and Genetics, University of Colorado, School of Medicine, 80206 Denver, Colorado, USA |
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| Abstract: | Summary The synthesis of the adenylate cyclase [ATP pyrophosphatelyase-(cyclizing), E.C. 4.6.1.1.] of Escherichia coli, appears to be regulated negatively by the cAMP receptor protein CRP. This conclusion is based on a comparison of adenylate cyclase activities measured in vitro with the rates of cAMP synthesis by intact bacteria. The activity of adenylate cyclase, depending on conditions of growth, is also regulated by CRP; this effect, however, is indirect insofar as it is mediated by a protein or proteins under CRP control. |
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