Genome-Wide Search for Host Association Factors during Ovine Progressive Pneumonia Virus Infection |
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| Authors: | Jesse Thompson Fangrui Ma Meghan Quinn Shi-Hua Xiang |
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| Affiliation: | 1. Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, Nebraska, United States of America;2. School of Veterinary Medicine and Biological Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, United States of America;3. School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, United States of America;University of Missouri, UNITED STATES |
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| Abstract: | Ovine progressive pneumonia virus (OPPV) is an important virus that causes serious diseases in sheep and goats with a prevalence of 36% in the USA. Although OPPV was discovered more than half of a century ago, little is known about the infection and pathogenesis of this virus. In this report, we used RNA-seq technology to conduct a genome-wide probe for cellular factors that are associated with OPPV infection. A total of approximately 22,000 goat host genes were detected of which 657 were found to have been significantly up-regulated and 889 down-regulated at 12 hours post-infection. In addition to previously known restriction factors from other viral infections, a number of factors which may be specific for OPPV infection were uncovered. The data from this RNA-seq study will be helpful in our understanding of OPPV infection, and also for further study in the prevention and intervention of this viral disease. |
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