Prostaglandins and oxytocin: Their effects on uterine smooth muscle |
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Authors: | Mary E Carsten |
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Institution: | Department of Obstetrics and Gynecology Mary E. Carsten Research Laboratory University of California at Los Angeles School of Medicine Los Angeles, California 90024, USA |
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Abstract: | A subcellular fraction was isolated from uteri of non-pregnant and pregnant cows. ATP-dependent calcium binding was shown to take place in this fraction. This calcium binding was inhibited in a dose related fashion when increasing amounts of prostaglandin (PG) E2 or F2α were added to the in vitro experimental medium. The physiologically inactive PGF1β had no inhibitory effect. Oxytocin caused inhibition of calcium binding in preparations from both pregnant and non-pregnant cows. The response to PGE2 and PGF2α was somewhat greater in preparations from pregnant uteri than from non-pregnant uteri. The response to oxytocin was very much greater in pregnant uteri. Because of the high PG sensitivity of calcium binding in preparations from the non-pregnant uterus, it is concluded that the PGs may be the more suitable agent in the control of reproduction. |
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