Immunocytochemical detection of triphosphoinositide in vestibular hair cells |
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Authors: | M. Tachibana H. Morioka M. Machino F. Mizukoshi O. Mizukoshi T. Yoshioka |
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Affiliation: | (1) Department of Otolaryngology, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamikyo-ku, 602 Kyoto, Japan;(2) Laboratory of Electronmicroscopy, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamikyo-ku, 602 Kyoto, Japan;(3) Department of Physiology, Yokohama City University School of Medicine, Japan |
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Abstract: | Summary Triphosphoinositide (TPI), an aminoglycoside receptor and a possible regulator of cationic permeation through its ability to bind with Ca++, was localized by the protein-A gold technique in vestibular sensory epithelia using an antibody highly specific to TPI. TPI was detected on the stereocilia, kinocilia, and cuticular plate of hair cells, and in the reticular membrane of supporting cells. The cilia of hair cells are damaged by aminoglycosides at a relatively early stage of toxicity. Ca++-regulated bioactivity in this area is probably involved. |
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