急性冠脉综合征患者PAPP-A基因IVS6+95(C/G)多态性与血浆PAPP-A水平及斑块性质的相关性

为研究湖北十堰地区急性冠脉综合征(ACS)患者PAPP-A基因IVS6 +95(C/G)多态性与血浆PAPP-A水平和斑块性质的相关性,随机选择215例ACS患者(包括58例急性心肌梗死(AMI)患者、73例不稳定型心绞痛(UAP)患者和84例稳定型心绞痛(SAP)患者)及142例健康对照者作为研究对象,检测PAPP-A基因IVS6+ 95 (C/G)多态性和血浆PAPP-A浓度,并进行统计学分析.结果显示,AMI组、UAP组和SAP组的PAPP-A浓度具有极显著差异(p＜0.01),在稳定性斑块和易损性斑块组间的PAPP-A浓度亦具有极显著差异(p＜0.01);AMI组、UAP组和SAP组与对照组间的基因型频率和等位基因频率具有显著差异(p＜0.05);在ACS组和对照组中,组内各类基因型人群的血浆PAPP-A浓度的差异不显著(p＞0.05).结果表明,PAPP-A基因IVS6+ 95多态性与急性冠脉综合征患者密切相关,血浆PAPP-A浓度与斑块性质相关,能够反映ACS患者斑块的易损性,是ACS患者危险分层的标志物.

PAPP-A Gene IVS6+95(C/G)Polymorphism and Plasma PAPP-A and Plaque Nature in Acute Coronary Syndrome Patient

To study the relationship between PAPP-A gene IVS6+95(C/G)polymorphism and plasma PAPP-A and the plaque nature in acute coronary syndrome(ACS)patients in Shiyan area,215ACS patients,including 58acute myocardial infarction patients(AMI),73unstable angina pectoris patients(UAP)and 84stable angina patients(SAP),and 142healthy control subjects were randomly selected,PAPP-A gene IVS6+95(C/G)polymorphism and plasma PAPP-A concentrations were detected,and the statistical analysis was performed.The results showed that plasma PAPP-A concentration was significantly different among AMI group,UAP group and SAP group(p<0.01),as well as between stable plaque group and vulnerable plaque group(p<0.01).IVS6+95C/G genotype frequencies and allele frequencies of the AMI,UAP and SAP groups were significantly different(p<0.05)compared with the control group.The conclusion of this study is that PAPP-A gene IVS6+95polymorphism is closely related to acute coronary syndrome,and the plasma PAPP-A can reflect the vulnerability of plaque in ACS patients.