Comparison of the antiviral action of different human interferons against DNA and RNA viruses |
| |
Authors: | Alberto Muñ oz,Luis Carrasco |
| |
Affiliation: | Departamento de Microbiología, Centro de Biología Molecular, Facultad de Ciencias, Universidad Autónoma, Canto Blanco, Madrid- 34, Spain |
| |
Abstract: | Abstract Five different interferon preparations were compared for their antiviral activity against Herpes simplex virus type 1 (HSV-1) and several RNA viruses. The interferons used were: interferon α from human buffy coats, interferon β from human fibroblasts, interferon γ from human lymphocytes after stimulation with phytohemagglutinin (PHA), lymphoblastoid interferon from Namalva cells IFN-α (Ly) and cloned α 2 interferon produced by Escherichia coli containing the human gene for interferon α 2. All preparations were able to protect monolayers of HeLa cells against HSV-1 infection when low multiplicities were used. The five IFN preparations were also tested against encephalomyocarditis (EMC) virus, poliovirus and vesicular stomatitis virus (VSV). |
| |
Keywords: | Interferon herpes virus poliovirus antiviral activity |
本文献已被 ScienceDirect 等数据库收录! |
|