A journey with T cells, primate/human retroviruses and other persisting human T-cell tropic viruses |
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| Authors: | Gallo Robert C |
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| Affiliation: | Institute of Human Virology, University of Maryland Biotechnology Institute, Department of Microbiology and Immunology and Department of Medicine, School of Medicine, 725 W. Lombard Street, Baltimore, MD 21201, USA. gallo@umbi.umd.edu |
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| Abstract: | A study of the growth of primate/human T cells led to mechanisms for temporary laboratory culture of these cells (discovery of interleukin-2) and also their continuous culture (by immortalization after infection with human T-cell lymphotropic virus type 1 or 2 (HTLV-1 or 2)). Cultures of lymphocytes also led us to isolate five persisting T-tropic viruses: 1. the Hall's Island strain of gibbon ape leukemia virus, 2. HTLV-1, 3. HTLV-2, 4. human immunodeficiency virus and 5. human herpes virus-6 (HHV-6). This report is a brief synopsis of the discoveries of the first human retroviruses, the HTLV. |
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