An intracellular Ca2+ subsystem as a biologically plausible source of intrinsic conditional bistability in a network model of working memory |
| |
Authors: | Christopher P Fall John Rinzel |
| |
Institution: | (1) Department of Anatomy and Cell Biology, University of Illinois at Chicago Medical Center, 808 South Wood St., Room 578, M/C 512, Chicago, IL, 60612;(2) Center for Neural Science and Courant Institute of Mathematical Sciences, New York University, New York |
| |
Abstract: | We have developed a firing rate network model for working memory that combines Mexican-hat-like synaptic coupling with intrinsic
or cellular dynamics that are conditionally bistable. While our approach is in the spirit of Camperi and Wang (1998) we include
a specific and plausible mechanism for the cellular bistability. Modulatory neurotransmitters are known to activate second
messenger signaling systems, and our model includes an intracellular Ca2+ handling subsystem whose dynamics depend upon the level of the second messenger inositol 1,4,5 trisphosphate (IP3). This
Ca2+ subsystem endows individual units with conditional intrinsic bistability for a range of IP3. The full “hybrid” network sustains
IP3-dependent persistent (“bump”) activity in response to a brief transient stimulus. The bump response in our hybrid model,
like that of Camperi-Wang, is resistant to noise – its position does not drift with time.
Action Editor: Upinder Bhalla |
| |
Keywords: | persistent activity working memory computational model calcium signaling inositol 1 4 5 trisphosphate neuromodulators |
本文献已被 PubMed SpringerLink 等数据库收录! |
|