Effects of static magnetic fields on nicotinic cholinergic receptor function |
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Authors: | Tolosa María Fernanda Bouzat Cecilia Cravero Walter Rubén |
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Institution: | Departamento de Física, Universidad Nacional del Sur, Bahía Blanca, Argentina. |
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Abstract: | Ligand-gated ion channel kinetics were studied in mammalian transfected cells encoding adult mouse muscle acetylcholine (ACh) receptors. We measured macroscopic and single-channel currents using the outside-out and cell-attached patch-clamp configurations. Cultured cells were exposed to moderate intensity inhomogeneous static magnetic fields up to 180 mT and measurements were performed for temperatures ranging from 5 to 50 °C. We found no significant changes in ACh-elicited macroscopic or single-channel currents. We observed the expected dependence in current decay constants with temperature, but negligible magnetic field influence on the channel's kinetics. |
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Keywords: | AChR patch‐clamp static magnetic field |
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