TGF-β1基因SNPs与长沙汉族人群 脑卒中的相关性研究

目的:通过对长沙汉族人群TGFB1的多态分布规律的研究,从遗传流行病学的角度探讨TGFB1SNPs（单核甘酸多态性）与长沙汉族人群脑卒中的关系.方法:应用PCR、RFLP及DNA直接测序等方法对研究人群进行-509C＞T及+869T＞C基因分型.研究对象包括:脑梗死(CI)患者186例,脑出血(CH)患者202例,正常...

A Research on the Relationship between the TGFB1 SNPs and Stroke in Han People in Changsha Area

Abstract： OBJECTIVE：Through researching of the TGFB1 SNP of Han population in Changsha area, tile relationship between the TGFB1 SNPs and the stroke in this area has been explored. METHOD ：The genotypes of 186 patients with cerebral infarction, 202 patients with primary cerebral hemorrhage and 160 sex- and age-matched heath controls from Hart population in Changsha area were detected by PCR-RFLP and direct DNA sequencing. RESULT：The frequencies of the -509C 〉 Tand ＋ 869T 〉 C genotypes and alleles showed no difference between the CI and the control groups, and no difference was found between the CH and the control groups （ P 〉 0.05 ） , either. But the frequencies of -509T and ＋ 869C carriers in FCI were higher than control group. The stroke prevalences of the -509T carriers in FCI were 1. 557 multiples compared to the control group, while the ＋ 869C carriers in FCI were 1.45 multiples compared to the control group. CONCLUSION： TGFB1 -509C 〉 T and ＋ 869T 〉 C are associated with cerebral infarction of people with a familyhistory of cerebral infarction, but have no relationship with cerebral hemorrhage. -509 T and ＋ 869C alleles are probably the risk factors of stroke of people with history of cerebra/infarction.