|
|||||
|
|
2-Aryl benzimidazoles featuring alkyl-linked pendant alcohols and amines as inhibitors of checkpoint kinase Chk2 |
|
| Authors: | Neff Danielle K Lee-Dutra Alice Blevitt Jonathan M Axe Frank U Hack Michael D Buma Johnathan C Rynberg Raymond Brunmark Anders Karlsson Lars Breitenbucher J Guy |
| Affiliation: | Johnson & Johnson Pharmaceutical Research & Development, L.L.C, 3210 Merryfield Row, San Diego, CA 92121, USA. dneff1@prdus.jnj.com |
| Abstract: | A series of benzimidazole compounds containing pendant alcohol and amine moieties was found to be active against checkpoint kinase Chk2. These compounds were prepared to examine a potential hydrogen bond interaction with an active site residue and to investigate replacement of a biaryl linker with an aliphatic system in an effort to improve solubility. |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |