Antiviral Activity of Polyacrylic and Polymethacrylic Acids: I. Mode of Action in Vitro. |
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| Authors: | P De Somer E De Clercq A Billiau E Schonne and M Claesen |
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| Institution: | Rega Institute for Medical Research, University of Leuven, Leuven, Belgium |
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| Abstract: | Polyacrylic acid (PAA) and polymethacrylic acid (PMAA) were investigated for their antiviral properties in tissue culture. Compared to other related polyanions, as dextran sulfate, polystyrene sulfonate, polyvinyl sulfate, and polyphloroglucinol phosphate, PAA and PMAA were found to be significantly more antivirally active and less cytotoxic. PMAA added 24 hr prior to virus inoculation inhibited viral growth most efficiently but it was still effective when added 3 hr after infection. Neither a direct irreversible action on the virus nor inhibition of virus penetration into the cell could explain the antiviral activity of PMAA. PMAA inhibited the adsorption of the virus to the host cell and suppressed the one-cycle viral synthesis in tissue cultures inoculated with infectious RNA. |
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