Effect of a novel insulinotropic agent, succinic acid monoethyl ester, on lipids and lipoproteins levels in rats with streptozotocin-nicotinamide-induced type 2 diabetes |
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Authors: | Ramalingam Saravanan Leelavinothan Pari |
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Institution: | (1) Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, 608 002 Annamalainagar, India |
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Abstract: | In the present study, the effect of succinic acid monoethyl ester (EMS) on the pattern of lipids and lipoproteins in streptozotocin-nicotinamide
induced type 2 diabetes was investigated. Type 2 diabetes was induced in male Wistar rats by single intraperitoneal injection
(i.p.) of 45 mg/kg streptozotocin, 15 min after the i.p administration of 110 mg/kg body weight of nicotinamide. The carboxylic
nutrient EMS was administered intraperitonially at a dose of 8 Μmol/g body weight for 30 days. At the end of experimental
period, the effect of EMS on plasma glucose, insulin, thiobarbituric acid reactive substances (TBARS) and hydroperoxide (HP)
and serum triglycerides (TG), phospholipids (PL), free fatty acids (FFA), total cholesterol (TC), very low density lipoprotein-cholesterol
(VLDL-C) and low density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C) and the percentage
of antiatherogenic index (AAI) (ratio of HDL-C to total cholesterol) were studied. Administration of EMS to diabetic rats
resulted in a signi. cant reduction in the elevated levels of plasma glucose, TBARS and hydroperoxides as well as TG, PL,
FFA, TC, VLDL-C and LDC-C levels. The decreased plasma insulin and serum HDL-C and percentage of AAI in diabetic rats were
also reversed towards near normal. The effect produced by EMS was compared with metformin, a reference drug. The results indicates
that the administration of EMS and metformin to nicotinamide-streptozotocin diabetic rats normalized plasma glucose, insulin
concentrations and caused marked improvement in altered lipids, lipoprotein and lipid peroxidation markers during diabetes.
Our results show the antihyperlipidemic properties of EMS and metformin in addition to its antidiabetic action. Moreover,
the antihyperlipidemic effect could represent a protective mechanism against the development of atherosclerosis. |
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Keywords: | Antiatherogenic index cholesterol lipoproteins phospholipids triglycerides type 2 diabetes |
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