| 一个基于熵的指数精细定位人类复杂性状位点 |
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| 引用本文： | 李玉梅,向阳.一个基于熵的指数精细定位人类复杂性状位点[J].生物数学学报,2011(2):279-285. |
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| 作者姓名： | 李玉梅 向阳 |
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| 作者单位： | 怀化学院数学系数学所; |
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| 基金项目： | supported by Foundation of Hunan Educational Committee(09C753); Scientific Research Found of Huaihua University(HHUZ2008-01) |
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| 摘 要： | 近来，一个基于熵的指数被提出用来对人类复杂性状位点进行连锁不平衡定位．这个熵指数比较了患病个体与正常个体或极端样本之间标记基因频率的熵和条件熵．本文基于熵理论，提出了另一个备选指数．这个新的指数比较患病个体与正常个体之间标记基因型频率的熵和条件熵．计算机模拟结果表明本文提出的新指数平行于之前的熵指数．而基于遗传性血色病（hereditary haemochromatosis，HH）数据的分析表明了这个新指数能有效对人类复杂性状位点进行精细定位．
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| 关 键 词： | 熵 连锁不平衡 基于熵的指数 精细定位 |
A Measure for Fine-scale Mapping of Human Complex Traits via Entropy |
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| LI Yu-mei XIANG Yang.A Measure for Fine-scale Mapping of Human Complex Traits via Entropy[J].Journal of Biomathematics,2011(2):279-285. |
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| Authors: | LI Yu-mei XIANG Yang |
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| Institution: | LI Yu-mei XIANG Yang (Mathematics Department and Mathematic Institute of Huaihua University,Huaihua Hunan 418000 China) |
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| Abstract: | An entropy-based measure,which compared the entropy and the conditional entropy in marker allele frequencies between cases and controls or in extreme samples of populations,has recently been proposed for linkage disequilibrium mapping of human complex trait.In this paper,based on Shannon entropy,we present an alternative measure by comparing the entropy and the conditional entropy in marker genotype frequencies in affected and unaffected individuals.A simulation study showed that the measure here is paralle... |
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| Keywords: | Entropy Linkage disequilibrium Entropy-based measure Fine mapping |
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