| 微生物连续发酵酶催化动力系统的鲁棒性与并行计算 |
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| 引用本文： | 张誉铎,张玉娟,冯恩民. 微生物连续发酵酶催化动力系统的鲁棒性与并行计算[J]. 生物数学学报, 2011, 0(3): 524-532 |
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| 作者姓名： | 张誉铎 张玉娟 冯恩民 |
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| 作者单位： | 大连理工大学数学科学学院;鞍山师范学院数学系; |
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| 基金项目： | 国家自然科学基金面上项目(批准号:10671126,10871033); 973项目(批准号:2007CB14306); 863项目:(批准号2007AA02Z208) |
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| 摘 要： | 依据甘油连续发酵生产1,3-丙二醇的非线性酶催化动力系统.针对1,3-丙二醇可能存在的跨膜运输方式建立相应的动力学模型,提出了酶催化动力系统的定量鲁棒性定义,并建立了以鲁棒性为性能指标、非线性动力系统为主要约束的参数辨识模型.由于求解该辨识问题的数值计算量大,在普通的PC机上难以完成,因此本文构建了相应的并行算法.根据数值结果推断出1,3-丙二醇最有可能的跨膜运输方式,这对于进一步研究甘油连续发酵的机理具有重要的参考价值.
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| 关 键 词： | 连续发酵 非线性酶催化动力系统 并行计算 鲁棒性分析 |
Robustness Analysis of Microbial Continuous Fermentation Based on Parallel Computing |
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| ZHANG Yu-duo ZHANG Yu-juan FENG En-min. Robustness Analysis of Microbial Continuous Fermentation Based on Parallel Computing[J]. Journal of Biomathematics, 2011, 0(3): 524-532 |
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| Authors: | ZHANG Yu-duo ZHANG Yu-juan FENG En-min |
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| Affiliation: | ZHANG Yu-duo~1 ZHANG Yu-juan~2 FENG En-min~1 (1 Department of Applied Mathematics,Dalian University of Technology,Dalian Liaoning 116024 China) (2 Department of Mathematics,Anshan Normal University,Anshan Liaoning 114007 China) |
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| Abstract: | In this paper,the non-linear enzyme-catalytic kinetic system of continuous fermentation in the process of glycerol bio-dissimilation is investigated.We establish various dynamical systems according to the possible transport mechanisms of 1,3-propanediol across cell membrane.We propose a new quantitative robustness index for the considered systems,which, together with the relative error between experimental data and computational results,is taken as a performance index for the subsequent identification model... |
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| Keywords: | Continuous fermentation Non-linear enzyme-catalytic kinetic system Parallel computing Robustness analysis |
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