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Triggering the production of the cryptic blue pigment indigoidine from Photorhabdus luminescens |
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| Authors: | Brachmann Alexander O Kirchner Ferdinand Kegler Carsten Kinski Sebastian C Schmitt Imke Bode Helge B |
| Affiliation: | a Molekulare Biotechnologie, Institut für Molekulare Biowissenschaften, Goethe Universität Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany b Biodiversität und Klima Forschungszentrum (BiK-F), Goethe Universität Frankfurt, Senckenberganlage 25, 60325 Frankfurt am Main, Germany |
| Abstract: | The production of the blue pigment indigoidine has been achieved in the entomopathogenic bacterium Photorhabdus luminescens by a promoter exchange and in Escherichia coli following heterologous expression of the biosynthesis gene indC. Moreover, genes involved in the regulation of this previously “silent” biosynthesis gene cluster have been identified in P. luminescens. |
| Keywords: | Secondary metabolite Biosynthesis gene cluster activation Promoter exchange Heterologous expression |
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