|
|||||
|
|
Study of skin anti-ageing and anti-inflammatory effects of dihydroquercetin, natural triterpenoinds, and their synthetic derivatives |
|
| Authors: | Chan Woo Lee Nok Hyun Park Jin Woong Kim Byung Hun Um A V Shpatov E E Shults I V Sorokina S A Popov |
| Institution: | 1. Amore-Pacific Co. R&D Center, 314-1, Bora-dong, Giheung-gu, Yongin-si, Gyeonggi-Do, 446-729, Republic of Korea 2. Dept. of Applied Chemistry, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan, Kyeonggi-do, 426-791, Republic of Korea 3. Natural Products Research Center, Korea Institute of Science and Technology (KIST) Gangneung Institute, Gangneung, 210-340, Gangwon-do, Republic of Korea 4. Novosibirsk Institute of Organic Chemistry, Lavrentyev Ave. 9, Novosibirsk, 630090, Russian Federation |
| Abstract: | Accessible triterpenoids of ursane and lupane series, the flavonoid dihydroquercetin and their synthetic derivatives with polar substituents were tested in vitro for inhibition of collagenase 1 (MMP-1) in UVB irradiation assay. Ursolic acid and uvaol disuccinate were the most active inhibitors in the ursane series. In the lupane series, the best inhibition was manifested by carboxymethyl ester of betulonic acid and betulin succinates. Down- regulation of MMP-1 by dihydroquercetin and its synthetic derivatives surpassed the activity of a standard (retinoic acid). |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |