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Synthesis and antitumor properties of the myelopeptide MP-1 |
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| Authors: | L A Fonina E M Treshchalina R G Belevskaya A A Az’muko M A Efremov L A Sedakova E A Kirilina |
| Institution: | 1. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia 3. Research Center of Experimental Therapy and Diagnosis of Tumors, Blokhin Center of Oncology, Russian Academy of Medical Sciences, Kashirskoe sh. 24, Moscow, 115478, Russia 2. Research Institute of Experimental Cardiology, Russian Cardiology Scientific and Production Association, Ministry of Health of the Russian Federation, Moscow, Russia |
| Abstract: | The bone marrow-derived peptide Phe-Leu-Gly-Phe-Pro-Thr (MP-1) has been synthesized by the classical methods of peptide chemistry in solution, and its antitumor properties have been studied. It has been shown that MP-1 enhances the efficacy of the cytostatic therapy of lympholeukosis P388, increases the latent period of the growth of P388 tumors implanted in irradiated mice, and reduces the recurrence of the breast adenocarcinoma Ca-755 in mice after the surgery. |
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