Biosynthesis, remodelling and functions of mammalian GPI-anchored proteins: recent progress |
| |
| Authors: | Kinoshita Taroh Fujita Morihisa Maeda Yusuke |
| |
| Institution: | WPI Immunology Frontier Research Center; Research Institute for Microbial Diseases, Osaka University, Osaka, Japan; CREST; and PREST, Japan Society of Technology, Saitama, Japan. |
| |
| Abstract: | More than 100 mammalian proteins are post-translationally modified by glycosylphosphatidylinositol (GPI) at their C-termini and are anchored to the cell surface membrane via the lipid portion. GPI-anchored proteins (GPI-APs) have various functions, such as hydrolytic enzymes, receptors, adhesion molecules, complement regulatory proteins and other immunologically important proteins. GPI-anchored proteins are mainly associated with membrane microdomains or membrane rafts enriched in sphingolipids and cholesterol. It is thought that association with membrane rafts is important for GPI-APs in signal transduction and other functions. Here, we review recent progress in studies on biosynthesis, remodelling and functions of mammalian GPI-APs. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
