The determinants of change in tibial plateau bone area in osteoarthritic knees: a cohort study |
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Authors: | Yuanyuan?Wang Anita?E?Wluka Email author" target="_blank">Flavia?M?CicuttiniEmail author |
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Institution: | (1) Department of Epidemiology and PreventiveMedicine, Monash UniversityMedical School, Alfred Hospital, Prahran, Vic, 3181, Australia;(2) Graduate School of IntegrativeMedicine, Swinburne University of Technology, Hawthorn, Vic, 3122, Australia |
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Abstract: | Bone is integral to the pathogenesis of osteoarthritis (OA). Whether the bone area of the tibial plateau changes over time
in subjects with knee OA is unknown. We performed a cohort study to describe this and identify factors that might influence
the change. One hundred and twenty-six subjects with knee OA underwent baseline knee radiography and magnetic resonance imaging
on their symptomatic knee. They were followed up with a repeatmagnetic resonance image of the same knee approximately 2 years
later. The bone area of the tibial plateau was measured at baseline and follow-up. Risk factors assessed at baseline were
tested for their association with change in tibial plateau bone area over time. One hundred and seventeen subjects completed
the study. The medial and lateral tibial plateau bone areas increased by 2.2 ± 6.9% and 1.5 ± 4.3% per year, respectively.
Being male (P = 0.001), having a higher body mass index (P = 0.002), and having a higher baseline grade of medial joint-space narrowing (P = 0.01) were all independently and positively associated with an increased rate of enlargement of bone area of the medial
tibial plateau. A larger baseline bone area of the medial tibial plateau was inversely associated with the rate of increase
of that area (P < 0.001). No factor examined affected the rate of increase of the bone area of the lateral tibial plateau. In subjects with
established knee OA, tibial plateau bone area increases over time. The role of subchondral bone change in the pathogenesis
of knee OA will need to be determined but may be one explanation for the mechanism of action of risk factors such as body
mass index on knee OA. |
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